Bioavailability of finger millet (Eleusine coracana) phenolic compounds in rat as influenced by coadministered piperine.
IR@CSIR-CFTRI
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Relation |
http://ir.cftri.com/13403/
https://doi.org/10.1016/j.fbio.2017.06.008 |
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Title |
Bioavailability of finger millet (Eleusine coracana) phenolic compounds in rat as influenced by coadministered piperine. |
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Creator |
Hithamani, G.
Srinivasan, K. |
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Subject |
05 Ragi (Finger Millet)
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Description |
Effect of co-administered piperine on the bioavailability of finger millet (FM) phenolic compounds was investigated in rats. FM phenolic extract was orally administered (100 mg kg−1) to rats along with or without piperine (20 mg kg−1). Blood, liver, intestine, kidney, and brain were analyzed for the absorbed phenolics at varying time intervals and their urinary excretion was monitored. Phenolic concentration in plasma was maximal at 8 h after oral administration of FM polyphenols (13 µg mL−1), salicylic acid being the predominant compound. Area under the curve (AUC) for phenolic concentration in plasma significantly increased (166 μg h mL−1 from 113) with piperine co-administration. Phenolic acids ̶ gentisic, sinapic, and ferulic acids were prominent in plasma when administered along with piperine. Phenolic concentration in liver, kidney, small intestine, and brain increased with piperine co-administration. Maximum appearance of phenolics in plasma, small intestine and kidney following the oral administration was advanced with piperine co-administration. FM-derived phenolics were found in brain at all time intervals, their concentration being higher when co-administered with piperine. Urinary phenolics excretion was higher when co-administered with piperine presumably because of higher absorption. Thus, piperine co-administration significantly increased absorption of orally administered FM phenolics and their retention in the body.
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Date |
2017
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Type |
Article
PeerReviewed |
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Format |
pdf
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Language |
en
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Identifier |
http://ir.cftri.com/13403/1/Food%20Bioscience%202017%20%282%29.pdf
Hithamani, G. and Srinivasan, K. (2017) Bioavailability of finger millet (Eleusine coracana) phenolic compounds in rat as influenced by coadministered piperine. Food Bioscience, 19. pp. 101-109. |
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