Record Details

Zinc supplementation alleviates the progression of diabetic nephropathy by inhibiting the overexpression of oxidative-stress-mediated molecular markers in streptozotocin-induced experimental rats.

IR@CSIR-CFTRI

View Archive Info
 
 
Field Value
 
Relation http://ir.cftri.com/13410/
https://doi.org/10.1016/j.jnutbio.2017.11.008
 
Title Zinc supplementation alleviates the progression of diabetic nephropathy by inhibiting
the overexpression of oxidative-stress-mediated molecular markers in
streptozotocin-induced experimental rats.
 
Creator Susmita, Barman
Pradeep, S. R.
Srinivasan, K.
 
Subject 13 Nutrition-Human
04 Diabetes Mellitus
 
Description Zinc deficiency during diabetes projects a role for zinc nutrition in the management of diabetic nephropathy. The current study explored whether zinc
supplementation protects against diabetic nephropathy through modulation of kidney oxidative stress and stress-induced expression related to the
inflammatory process in streptozotocin-induced diabetic rats. Groups of hyperglycemic rats were exposed to dietary interventions for 6 weeks with zinc
supplementation (5 times and 10 times the normal level). Supplemental-zinc-fed diabetic groups showed a significant reversal of increased kidney weight and
creatinine clearance. There was a significant reduction in hyperlipidemic condition along with improved PUFA:SFA ratio in the renal tissue. Expression of the
lipid oxidative marker and expression of inflammatory markers, cytokines, fibrosis factors and apoptotic regulatory proteins observed in diabetic kidney were
beneficially modulated by zinc supplementation, the ameliorative effect being concomitant with elevated antiapoptosis. There was a significant reduction in
advanced glycation, expression of the receptor of the glycated products and oxidative stress markers. Zinc supplementation countered the higher activity and
expression of polyol pathway enzymes in the kidney. Overexpression of the glucose transporters, as an adaptation to the increased need for glucose transport in
diabetic condition, was minimized by zinc treatment. The pathological abnormalities in the renal architecture of diabetic animals were corrected by zinc
intervention. Thus, dietary zinc supplementation has a significant beneficial effect in the control of diabetic nephropathy. This was exerted through a protective
influence on oxidative-stress-induced cytokines, inflammatory proliferation and consequent renal injury.
 
Date 2018
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/13410/1/Journal%20of%20Nutritional%20Biochemistry%2054%20%282018%29%20113%E2%80%93129.pdf
Susmita, Barman and Pradeep, S. R. and Srinivasan, K. (2018) Zinc supplementation alleviates the progression of diabetic nephropathy by inhibiting the overexpression of oxidative-stress-mediated molecular markers in streptozotocin-induced experimental rats. Journal of Nutritional Biochemistry, 54. pp. 113-129. ISSN 0955-2863