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Trace elements in Alzheimer's disease brain: A new hypothesis.

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Relation http://ir.cftri.com/13414/
 
Title Trace elements in Alzheimer's
disease brain: A new hypothesis.
 
Creator Jagannatha Rao, K. S.
Ranganath Rao, V.
Shanmugavelu, P.
Rani, B. Menon
 
Subject 02 Anatomy
 
Description Trace elements AI, Fe, Zn, Cu, S, P, Mg, Si, Ca, Na, and K, were analysed in normal, moderately
and severely affected Alzheimer's disease (AD) brains using Inductively Coupled Plasma Atomic
Emission Spectrometer (ICPAES). In moderately affected brains, the monovalent elements Potassium
and Phosphorus were significantly reduced, while divalent elements namely Calcium, Magnesium,
Zinc and Copper were increased. In severely affected AD brains, Aluminium. Sulphur and Iron
predominated. It was shown that Iron accumulates more in the brains of people with moderate and
severe AD, while Aluminium deposition is greater in the severely affected AD brain. All the above
results suggest that Iron deposits early in AD pathology while Aluminum deposits in the later phase
of AD. These are the first findings to provide evidence of the distribution of trace elements and their
inter-relationship with the severity of AD.
 
Date 1999
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/13414/1/Alz%20Report%202%284%29%201999%20241-246.pdf
Jagannatha Rao, K. S. and Ranganath Rao, V. and Shanmugavelu, P. and Rani, B. Menon (1999) Trace elements in Alzheimer's disease brain: A new hypothesis. Alzheimer's Reports, 2 (4). pp. 211-216.