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Evaluation of certain bioactive compounds using in ovo diabetic model.

IR@CSIR-CFTRI

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Relation http://ir.cftri.com/13420/
 
Title Evaluation of certain bioactive compounds
using in ovo diabetic model.
 
Creator Srinivasan, K.
Venkateswaran, G.
Muthukumar, S. P.
 
Subject 04 Diabetes Mellitus
 
Description Mammalian models are frequently used for drug research and delivery systems. However, valid mammalian
models are expensive, time consuming and not easy to set up and evaluate. Furthennore, they are often linked
with ethical and legal aspects. Many micro, macro nutrients and other photochemical from food materials
are found to possess many desirable health benefits. A large number of studies involving animals have
been carried out to explore these beneficial properties. As an alternative, chick embryo developed through
incubation of fertile chicken eggs has been used as a novel system to develop suitable models for biochemical
and neutraceutical research. The in ovo technique is accepted as an alternative to traditional mammalian
models and this can be suitably used in our routine biochemical tests, wherever the animal trials are not
feasible. In view of the above, the development and evaluation of certain bioactive components using in ova
technique as a diabetic model was carried out in our laboratory. Bixin decreased significantly the plasma
glucose, triglycerides, cholesterol, urea, creatinine and blood urea nitrogen, while liver glycogen levels in
treated diabetic chick embryos increased when compared to control diabetic chick embryos.
 
Date 2011
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/13420/1/Jl%20of%20Lab%20Animal%20Sci%201%281%29%202011%2034-.pdf
Srinivasan, K. and Venkateswaran, G. and Muthukumar, S. P. (2011) Evaluation of certain bioactive compounds using in ovo diabetic model. Journal of Laboratory Animal Science, 1 (1). pp. 34-38.