ICAR Research Data Repository for Knowledge Management
Nigerloxin, a novel inhibitor of aldose reductase and lipoxygenase with Free radical scavenging activity from Aspergillus niger CFR-W-105.
IR@CSIR-CFTRI
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| Relation |
http://ir.cftri.com/2086/
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| Title |
Nigerloxin, a novel inhibitor of aldose reductase and lipoxygenase with Free radical scavenging activity from Aspergillus niger CFR-W-105.
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| Creator |
Rao, K. C. Sekhar
Divakar, S. Babu, K. Naveen Rao, A. G. Appu Karanth, N. G. Sattur, A. P. |
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| Subject |
03 Fungi
05 Enzymes |
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| Description |
An enzyme inhibitor, nigerloxin, with inhibition against soy bean lipoxygenase-I (LOX-1), rat lens aldose reductase (RLAR) as well as free radical scavenging activity was isolated from the fermented wheat bran using Aspergillus niger CFR-W-105. Its chemical structure was identified as 2-amido-3-hydroxy-6-methoxy-5-methyl-4-(prop-1'-enyl) benzoic acid by NMR and GCEIMS data. The IC50 values against LOX-1 and RLAR were found to be 79 microM and 69 microM and ED50 against 1,1-diphenyl-2-picrylhydrazyl (DPPH) was 66 microM.
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| Date |
2002
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| Type |
Article
PeerReviewed |
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| Format |
pdf
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| Language |
en
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| Identifier |
http://ir.cftri.com/2086/1/The%20Journal%20of%20Antibiotics%202002.pdf
Rao, K. C. Sekhar and Divakar, S. and Babu, K. Naveen and Rao, A. G. Appu and Karanth, N. G. and Sattur, A. P. (2002) Nigerloxin, a novel inhibitor of aldose reductase and lipoxygenase with Free radical scavenging activity from Aspergillus niger CFR-W-105. The Journal of antibiotics, 55 (9). pp. 789-93. ISSN 0021-8820 |
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