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Effect of zinc deprivation on the lipid metabolism of budding yeast.

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Relation http://ir.cftri.com/13434/
http://dx.doi.org/10.1007/s00294-017-0704-9
 
Title Effect of zinc deprivation on the lipid metabolism of budding
yeast.
 
Creator Neelima, Singh
Kamlesh Kumar, Yadav
Ram, Rajasekharan
 
Subject 22 Lipid Chemistry
19 Yeast
 
Description Zinc is an essential micronutrient for all living
cells. It serves as a structural and catalytic cofactor for
numerous proteins, hence maintaining a proper level of
cellular zinc is essential for normal functioning of the cell.
Zinc homeostasis is sustained through various ways under
severe zinc-deficient conditions. Zinc-dependent proteins
play an important role in biological systems and limitation of
zinc causes a drastic change in their expression. In budding
yeast, a zinc-responsive transcription factor Zap1p controls
the expression of genes required for uptake and mobilization
of zinc under zinc-limiting conditions. It also regulates the
polar lipid levels under zinc-limiting conditions to maintain
membrane integrity. Deletion of ZAP1 causes an increase in
triacylglyerol levels which is due to the increased biosynthesis
of acetate that serves as a precursor for triacylglycerol
biosynthesis. In this review, we expanded our recent work
role of Zap1p in nonpolar lipid metabolism of budding yeast.
 
Date 2017
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/13434/1/Curr%20Genet%20%282017%29%2063977%E2%80%93982.pdf
Neelima, Singh and Kamlesh Kumar, Yadav and Ram, Rajasekharan (2017) Effect of zinc deprivation on the lipid metabolism of budding yeast. Current Genetics, 63. pp. 977-982.