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Mxr1p is a Global Regulator of Multiple Metabolic Pathways in the Methylotrophic Yeast Pichia Pastoris
Electronic Theses of Indian Institute of Science
View Archive Info| Field | Value | |
| Title |
Mxr1p is a Global Regulator of Multiple Metabolic Pathways in the Methylotrophic Yeast Pichia Pastoris
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| Creator |
Sahu, Umakant
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| Subject |
Methanol Expression Regulator 1
Methylotrophic Yeast Pichia pastoris Mxr1p Methanol Utilization Pathway Pichia pastoris P. pastoris Zinc Finger Transcription Factor Multiple Metabolic Pathways Biochemistry |
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| Description |
The present study is aimed at examining the ability of Pichia pastoris to utilize acetate and amino acids as the sole sources of carbon. We demonstrate that the zinc finger transcription factor Mxr1p, which is a positive regulator of methanol metabolism, is also required for the growth of P. pastoris in media containing acetate or amino acids as the sole source of carbon. We have identified the target genes of Mxr1p in cells cultured in media containing acetate or amino acids as the sole carbon source. We conclude that Mxr1p is a global regulator of multiple metabolic pathways in P. pastoris.
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| Contributor |
Rangarajan, P N
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| Date |
2018-03-01T16:16:37Z
2018-03-01T16:16:37Z 2018-03-01 2016 |
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| Type |
Thesis
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| Identifier |
http://hdl.handle.net/2005/3212
http://etd.ncsi.iisc.ernet.in/abstracts/4075/G28356-Abs.pdf |
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| Language |
en_US
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| Relation |
G28356
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