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Studies on the metabolism of piperine: absorption, tissue distribution and excretion of urinary conjugates in rats.

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Title Studies on the metabolism of piperine: absorption, tissue distribution and excretion of urinary conjugates in rats.
 
Creator Bhat, B. G.
Chandrasekhara, N.
 
Subject 07 Metabolism
30 Spices/Condiments
 
Description Male albino rats were fed piperine, the major bite factor of black pepper, at a dose of 30 mg (170 mg/kg) by gavage or 15 mg (85 mg/kg) intraperitoneally. About 97% was absorbed irrespective of mode of dosing, 3% was excreted in faeces, but none was detectable in urine. Highest concn. of piperine in the stomach and small intestine was attained at about 6 h. Only traces were detected in serum, kidney and spleen from 30 min to 24 h.
 
Date 1986
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/6562/1/Toxicology%2C%2040%20%281986%29%2083--92.pdf
Bhat, B. G. and Chandrasekhara, N. (1986) Studies on the metabolism of piperine: absorption, tissue distribution and excretion of urinary conjugates in rats. Toxicology, 40 (1). 83-92, 20 ref..