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Hexachlorocyclohexane-induced testicular dysfunction in rats.

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Title Hexachlorocyclohexane-induced testicular dysfunction in rats.
 
Creator Shivanandappa, T.
Krishnakumari, M. K.
 
Subject 26 Pesticide Chemistry
17 Toxicology
 
Description Weanling male albino rats were fed 100, 750 and 1500 p.p.m. oftechnical HCH for90days. There was
marked testicular atrophy with reduced tubule size and spermatogenetic arrest at 1500 p.p.m. Histochemically,
there was accumulation of cholesterol-positive lipids in the Sertoli cells and the Leydig cells of the atrophied
testis and biochemical estimation revealed significant increase of total lipid and cholesterol contents. Activities
of As 3 0 hydroxysteroid dehydrogenase (A5 3 0 HSDH), 17 p hydroxysteroid dehydrogenase( I7 HSDH)and
glucose-6-phosphate dehydrogenase (G-6-PDH) in the interstitial cells were markedly decreased suggesting
steroidogenic inhibition in the Leydig cells of the atrophied testis due to HCH feeding.
 
Date 1983
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/4317/1/Acta%20pharmacol.%20et%20toxicol.%201983%2C%2052%2C%2012-17.pdf
Shivanandappa, T. and Krishnakumari, M. K. (1983) Hexachlorocyclohexane-induced testicular dysfunction in rats. Acta Pharmacologia and Toxicologie, 52. pp. 12-17.