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Inhibitory pattern of tissue esterases in rats fed dietary pirimiphos-methyl.

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Title Inhibitory pattern of tissue esterases in rats fed dietary pirimiphos-methyl.
 
Creator Rajini, P. S.
Muralidhara, Dr.
Krishnakumari, M. K.
 
Subject 26 Pesticide Chemistry
17 Toxicology
 
Description Activities of Acetylcholinesterase (AChE) in brain and erythrocytes, pseudocholinesterase (PChE) in plasma and non-specific carboxylesterase (NSE) in brain, liver, plasma and kidney were assayed at weekly intervals in growing male rats fed dietary pirimiphos-methyl at dosages of 1000, and 1500 ppm for a period of 28 days. Significant inhibition of tissue esterases were observed at the end of 7 days at both the dosages and the enzyme activities remained markedly inhibited at subsequent intervals. Activities of all enzymes (excepting Brain AChE) returned to normal levels following a 7-day maintenance on the insecticide-free diet implicating that pirimiphos-methyl induced little or no permanent tissue damage. The results suggest that plasma NSE level may also serve as a sensitive indicator in monitoring OPI exposure.
 
Date 1989
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/2354/1/J.%20ENVIRON.%20SCI.%20HEALTH%2C%20B24%285%29%2C%20509-524%20%281989%29.pdf
Rajini, P. S. and Muralidhara, Dr. and Krishnakumari, M. K. (1989) Inhibitory pattern of tissue esterases in rats fed dietary pirimiphos-methyl. Journal of Evironmental Science and Health. Part. B, Pesticides, food contaminants, and agricultural wastes, 24 (5). pp. 509-24. ISSN 0360-1234