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Biochemical changes produced by beta- and gamma-hexachlorocyclohexane isomers in albino rats.

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Title Biochemical changes produced by beta- and gamma-hexachlorocyclohexane isomers in albino rats.
 
Creator Srinivasan, K.
Radhakrishnamurty, R.
 
Subject 07 Enzyme Biochemistry
17 Toxicology
 
Description Administration of beta- and gamma-isomers of hexachlorocyclohexane (HCH) at 800 ppm dietary level for 2 weeks to albino rats produced noticeable hepatocellular damage as indicated by elevations in serum aminotransferases and decreases in hepatic soluble enzymes. Although serum total LDH activity was not altered, the LD5 isoenzyme was proportionately higher in the HCH isomers treated animals. Treatment of rats with beta- and gamma-isomers of HCH increased the hepatic glucose-6-phosphate dehydrogenase and aldolase activities suggesting a higher rate of glucose oxidation. Liver glucose-6-phosphatase activity was decreased in these animals indicating inactivation of gluconeogenesis in liver. Dietary beta- and gamma-HCH decreased the liver mitochondrial DNP/Mg++/Ca++-activated ATPases thus affecting the energy metabolism. An unaltered ratio of DNP/Mg++-ATPase, a study of swelling pattern of hepatic mitochondria, and NAD+ permeability test suggested the maintenance of structural integrity of mitochondrial membrane in these pesticide fed animals. Liver microsomal Na+,K+-ATPases were lower in these animals.
 
Date 1988
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/2368/1/J%20.%20ENVIRON.%20SCI.%20HEALTH%2C%20B23%284%29%2C%20367-386%20%281988%29.pdf
Srinivasan, K. and Radhakrishnamurty, R. (1988) Biochemical changes produced by beta- and gamma-hexachlorocyclohexane isomers in albino rats. Journal of Environmental Science and Health. Part. B, Pesticides, food contaminants, and agricultural wastes, 23 (4). pp. 367-86. ISSN 0360-1234