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Lipid peroxide induced DNA damage: protection by turmeric (Curcuma longa).

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Relation http://ir.cftri.com/2379/
 
Title Lipid peroxide induced DNA damage: protection by turmeric (Curcuma longa).
 
Creator Shalini, V. K.
Srinivas, L.
 
Subject 11 Lipid Biochemistry
07 Turmeric
 
Description Liposomal lipid peroxidation and peroxide induced DNA damage were investigated. Inhibition of lipid peroxidation was studied using 400 microM uric acid, beta-carotene, alpha-tocopherol, curcumin and butylated hydroxyanisole (BHA). Curcumin, the active principle of turmeric (Curcuma longa), was as effective an antioxidant as BHA. An aqueous extract of turmeric was also found to be an effective inhibitor. The inhibition obtained using this aqueous extract, incorporated into the liposome itself, was 70% at 300 ng/microliter. This indicates the presence of yet another antioxidant in turmeric besides the lipophilic curcumin. The aqueous antioxidant extended 80% protection to DNA against peroxidative injury at 100 ng/microliter. This component of turmeric is being characterised and investigated as an antioxidant/anticlastogen and as an antipromoter.
 
Date 1987
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/2379/1/Molecular%20and%20Cellular%20Biochemistry%2077%203-10%20%281987%29.pdf
Shalini, V. K. and Srinivas, L. (1987) Lipid peroxide induced DNA damage: protection by turmeric (Curcuma longa). Molecular and Cellular Biochemistry, 77 (1). pp. 3-10. ISSN 0300-8177