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Effect of vitamin A on hexachlorocyclohexane (HCH) toxicity in the rat.

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Title Effect of vitamin A on hexachlorocyclohexane (HCH) toxicity in the rat.
 
Creator Joseph, P.
Shivanandappa, T.
Narasimhamurthy, K.
Krishnakumari, M. K.
 
Subject 26 Pesticide Chemistry
17 Toxicology
04 Vitamins
 
Description 1. Technical hexachlorocyclohexane (HCH) depleted hepatic stores of vitamin A in male albino rats to cause secondary vitamin A deficiency. 2. Toxicity of HCH in rats is augmented by dietary vitamin A-deficiency as evidenced by growth retardation, organ hypertrophies and alterations in the serum and liver levels of the marker enzymes of toxicity. 3. Supplementation of dietary vitamin A to the rats either in adequate (2000 IU/kg diet) or in an excess but not hypervitaminotic level (10(5) IU/kg diet) resulted in significant protection against the toxicity of HCH. 4. The activities of the hepatic xenobiotic metabolizing enzymes were generally low (with the exception of glutathione S-transferase) in the vitamin A-deficient rats compared to those of the vitamin A supplemented diet groups. 5. The results indicated that dietary vitamin A influences the response of male albino rats to HCH toxicity possibly by modulating the activities of hepatic xenobiotic metabolizing enzymes.
 
Date 1992
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/2305/1/Gen%20Pharmac%20Vol%2023%2C%20No%206%2C%20pp%201159-1164%2C%201992.pdf
Joseph, P. and Shivanandappa, T. and Narasimhamurthy, K. and Krishnakumari, M. K. (1992) Effect of vitamin A on hexachlorocyclohexane (HCH) toxicity in the rat. General Pharmacology, 23 (6). pp. 1159-64. ISSN 0306-3623