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Effect of maternal dietary hexachlorocyclohexane exposure on pup survival and growth in albino rats.

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Title Effect of maternal dietary hexachlorocyclohexane exposure on pup survival and growth in albino rats.
 
Creator Srinivasan, K.
Mahadevappa, K. L.
Radhakrishnamurty, R.
 
Subject 26 Pesticide Chemistry
17 Toxicology
 
Description In adult albino rats, maternal dietary beta- and gamma-hexachlorocyclohexane (HCH) intake during gestation upto 400 ppm level did not affect the number of litters produced. But about 50 and 100% pup mortality was found in 200 and 400 ppm beta-HCH group within 5 days of birth. Maternal mortality was observed in 800 ppm beta-HCH group during third week of gestation. The effect of maternal dietary intake of HCH isomers at 50 and 250 ppm level during gestation and/or lactation on perinatal development was also studied. The body weights and sizes of the newborn litters of mother rats exposed to dietary HCH isomers did not differ from controls. Similarly, the growth and development of the litters of HCH exposed mother rats that survived 28 day lactation period were found to be comparable to controls as evidenced by the body weight and weight of vital organs. However, liver weight increases were found in the 28 days weaned litters wherever the mothers had been exposed to HCH isomers during lactation. Lowered kidney weight was seen in litters of mother rats fed 250 ppm gamma-HCH during gestation and lactation. The brain and testis weights were not affected in the litters of any experimental groups.
 
Date 1991
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/2331/1/J.%20ENVIRON.%20SCI.%20HEALTH%2C%20B26%283%29%2C%20339-349%20%281991%29.pdf
Srinivasan, K. and Mahadevappa, K. L. and Radhakrishnamurty, R. (1991) Effect of maternal dietary hexachlorocyclohexane exposure on pup survival and growth in albino rats. Journal of Environmental Science and Health. Part. B, Pesticides, food contaminants, and agricultural wastes, 26 (3). pp. 339-49. ISSN 0360-1234