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Alteration in the Gut Microbiota Provokes Susceptibility to Tuberculosis

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Alteration in the Gut Microbiota Provokes Susceptibility to Tuberculosis
 
Creator Khan, Nargis
Vidyarthi, Aurobind
Nadeem, Sajid
Negi, Shikha
Nair, Girish
Agrewala, Javed N.
 
Subject QR Microbiology
 
Description The microbiota that resides in the gastrointestinal tract provides essential health benefits to the host. In particular, they regulate immune homeostasis. Recently, several evidences indicate that alteration in the gut microbial community can cause infectious and non-infectious diseases. Tuberculosis (TB) is the most devastating disease, inflicting mortality and morbidity. It remains unexplored, whether changes in the gut microbiota can provoke or prevent TB. In the current study, we have demonstrated the antibiotics driven changes in the gut microbial composition and their impact on the survival of Mycobacterium tuberculosis (Mtb) in the lungs, liver, and spleen of infected mice, compared to those with intact microbiota. Interestingly, dysbiosis of microbes showed significant increase in the bacterial burden in lungs and dissemination of Mtb to spleen and liver. Furthermore, elevation in the number of Tregs and decline in the pool of IFN-γ- and TNF-α-releasing CD4 T cells was noticed. Interestingly, fecal transplantation in the gut microbiota disrupted animals exhibited improved Th1 immunity and lesser Tregs population. Importantly, these animals displayed reduced severity to Mtb infection. This study for the first time demonstrated the novel role of gut microbes in the susceptibility to TB and its prevention by microbial implants. In future, microbial therapies may help in treating patients suffering from TB.
 
Publisher Frontiers Research Foundation
 
Date 2016
 
Type Article
PeerReviewed
 
Relation http://dx.doi.org/10.3389/fimmu.2016.00529
http://crdd.osdd.net/open/1968/
 
Identifier Khan, Nargis and Vidyarthi, Aurobind and Nadeem, Sajid and Negi, Shikha and Nair, Girish and Agrewala, Javed N. (2016) Alteration in the Gut Microbiota Provokes Susceptibility to Tuberculosis. Frontiers in Immunology, 7. ISSN 1664-3224