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Occurrence of Diverse Antimicrobial Resistance Determinants in Genetically Unrelated Biocide Tolerant Klebsiella pneumoniae

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Occurrence of Diverse Antimicrobial Resistance Determinants in Genetically Unrelated Biocide Tolerant Klebsiella pneumoniae
 
Creator Shukla, Deepak
Mondal, Amitabha
Venkataramaiah, Manjunath
Rajamohan, Govindan
Srinivasan, Vijaya Bharathi
 
Subject QR Microbiology
 
Description Nosocomial infections due to Klebsiella pneumoniae is a significant problem in health care settings worldwide. In this study, we examined the antimicrobial susceptibility, genetic profiles and mechanisms of antibiotic resistance in K. pneumoniae isolates of Indian origin. To our knowledge this is the first report demonstrating the high prevalence of β-lactamases, aminoglycoside modifying enzymes, quinolone resistance genes besides demonstrating the involvement of active efflux in K. pneumoniae Indian isolates. This study has enabled us to correlate the phenotypic and genotypic characteristics in K. pneumoniae, providing an important base for continued monitoring and epidemiological studies of this emerging nosocomial pathogen in Indian hospitals.
 
Publisher Public Library of Science
 
Date 2016
 
Type Article
PeerReviewed
 
Relation http://dx.doi.org/10.1371/journal.pone.0166730
http://crdd.osdd.net/open/1978/
 
Identifier Shukla, Deepak and Mondal, Amitabha and Venkataramaiah, Manjunath and Rajamohan, Govindan and Srinivasan, Vijaya Bharathi (2016) Occurrence of Diverse Antimicrobial Resistance Determinants in Genetically Unrelated Biocide Tolerant Klebsiella pneumoniae. PLOS ONE, 11 (11). e0166730. ISSN 1932-6203