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β-Endorphin enhances the phospholipase activity of the dandruff causing fungiMalassezia globosaandMalassezia restricta

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title β-Endorphin enhances the phospholipase activity of the dandruff causing fungiMalassezia globosaandMalassezia restricta
 
Creator Honnavar, Prasanna
Chakrabarti, Arunaloke
Prasad, Ghandam S
Singh, Pankaj
Dogra, Sunil
Rudramurthy, Shivaprakash M
 
Subject QR Microbiology
 
Description β-Endorphin is known to stimulate phospholipase production by Malassezia pachydermatis during canine dermatoses. The role of β-endorphin in Malassezia infection in humans is not well studied. The present study compares the influence of β-endorphin on Malassezia globosa and Malassezia restricta isolated from patients with seborrhoeic dermatitis/dandruff (SD/D) and healthy controls. Malassezia isolates (five each of the two species from patients and healthy controls) were grown on modified Dixon's agar with or without 100 nmol/L β-endorphin. Phospholipase activity was quantified based on its ability to hydrolyze L-α-phosphatidylcholine dimyristoyl (phospholipid substrate). Free fatty acid was measured by a colorimetry method. In isolates from patients, the phospholipase activity significantly increased after exposure to β-endorphin (M. globosa, P = .04; M. restricta, P = .001), which did not occur in isolates from healthy controls. Moreover, after β-endorphin exposure the patient isolates had significantly higher (P = .0004) phospholipase activity compared to the healthy control isolates. The results suggest that isolates of M. globosa and M. restricta from patients may differ from those of healthy humans.
 
Publisher Blackwell Science
 
Date 2016
 
Type Article
PeerReviewed
 
Relation http://dx.doi.org/10.1093/mmy/myw058
http://crdd.osdd.net/open/1959/
 
Identifier Honnavar, Prasanna and Chakrabarti, Arunaloke and Prasad, Ghandam S and Singh, Pankaj and Dogra, Sunil and Rudramurthy, Shivaprakash M (2016) β-Endorphin enhances the phospholipase activity of the dandruff causing fungiMalassezia globosaandMalassezia restricta. Medical Mycology, 55 (2). pp. 150-154. ISSN 1369-3786