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aBiofilm: a resource of anti-biofilm agents and their potential implications in targeting antibiotic drug resistance

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title aBiofilm: a resource of anti-biofilm agents and their potential implications in targeting antibiotic drug resistance
 
Creator Rajput, Akanksha
Thakur, Anamika
Sharma, Shivangi
Kumar, Manoj
 
Subject QR Microbiology
 
Description Biofilms play an important role in the antibiotic drug resistance, which is threatening public health globally. Almost, all microbes mimic multicellular lifestyle to form biofilm by undergoing phenotypic changes to adapt adverse environmental conditions. Many anti-biofilm agents have been experimentally validated to disrupt the biofilms during last three decades. To organize this data, we developed the 'aBiofilm' resource (http://bioinfo.imtech.res.in/manojk/abiofilm/) that harbors a database, a predictor, and the data visualization modules. The database contains biological, chemical, and structural details of 5027 anti-biofilm agents (1720 unique) reported from 1988-2017. These agents target over 140 organisms including Gram-negative, Gram-positive bacteria, and fungus. They are mainly chemicals, peptides, phages, secondary metabolites, antibodies, nanoparticles and extracts. They show the diverse mode of actions by attacking mainly signaling molecules, biofilm matrix, genes, extracellular polymeric substances, and many more. The QSAR based predictor identifies the anti-biofilm potential of an unknown chemical with an accuracy of ∼80.00%. The data visualization section summarized the biofilm stages targeted (Circos plot); interaction maps (Cytoscape) and chemicals diversification (CheS-Mapper) of the agents. This comprehensive platform would help the researchers to understand the multilevel communication in the microbial consortium. It may aid in developing anti-biofilm therapeutics to deal with antibiotic drug resistance menace.
 
Publisher Oxford University Press
 
Date 2018-01-04
 
Type Article
PeerReviewed
 
Relation http://dx.doi.org/10.1093/nar/gkx1157
http://crdd.osdd.net/open/2007/
 
Identifier Rajput, Akanksha and Thakur, Anamika and Sharma, Shivangi and Kumar, Manoj (2018) aBiofilm: a resource of anti-biofilm agents and their potential implications in targeting antibiotic drug resistance. Nucleic Acids Research, 46 (D1). D894-D900. ISSN 0305-1048