Record Details

Bioenergetics of Mycobacterium: An Emerging Landscape for Drug Discovery

DIR@IMTECH: CSIR-Institute of Microbial Technology

View Archive Info
 
 
Field Value
 
Title Bioenergetics of Mycobacterium: An Emerging Landscape for Drug Discovery
 
Creator Iqbal, Iram
Bajeli, Sapna
Akela, Ajit
Kumar, Ashwani
 
Subject QR Microbiology
 
Description Mycobacterium tuberculosis (Mtb) exhibits remarkable metabolic flexibility that enables it to survive a plethora of host environments during its life cycle. With the advent of bedaquiline for treatment of multidrug-resistant tuberculosis, oxidative phosphorylation has been validated as an important target and a vulnerable component of mycobacterial metabolism. Exploiting the dependence of Mtb on oxidative phosphorylation for energy production, several components of this pathway have been targeted for the development of new antimycobacterial agents. This includes targeting NADH dehydrogenase by phenothiazine derivatives, menaquinone biosynthesis by DG70 and other compounds, terminal oxidase by imidazopyridine amides and ATP synthase by diarylquinolines. Importantly, oxidative phosphorylation also plays a critical role in the survival of persisters. Thus, inhibitors of oxidative phosphorylation can synergize with frontline TB drugs to shorten the course of treatment. In this review, we discuss the oxidative phosphorylation pathway and development of its inhibitors in detail.
 
Publisher MDPI AG
 
Date 2018-02-23
 
Type Article
PeerReviewed
 
Relation http://dx.doi.org/10.3390/pathogens7010024
http://crdd.osdd.net/open/2013/
 
Identifier Iqbal, Iram and Bajeli, Sapna and Akela, Ajit and Kumar, Ashwani (2018) Bioenergetics of Mycobacterium: An Emerging Landscape for Drug Discovery. Pathogens, 7 (1). p. 24. ISSN 2076-0817