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Using Chou's general PseAAC to analyze the evolutionary relationship of receptor associated proteins (RAP) with various folding patterns of protein domains

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Using Chou's general PseAAC to analyze the evolutionary relationship of receptor associated proteins (RAP) with various folding patterns of protein domains
 
Creator Muthu Krishnan, S.
 
Subject QR Microbiology
 
Description The receptor-associated protein (RAP) is an inhibitor of endocytic receptors that belong to the lipoprotein receptor gene family. In this study, a computational approach was tried to find the evolutionarily related fold of the RAP proteins. Through the structural and sequence-based analysis, found various protein folds that are very close to the RAP folds. Remote homolog datasets were used potentially to develop a different support vector machine (SVM) methods to recognize the homologous RAP fold. This study helps in understanding the relationship of RAP homologs folds based on the structure, function and evolutionary history.
 
Publisher Elsevier
 
Date 2018-05-14
 
Type Article
PeerReviewed
 
Relation http://dx.doi.org/10.1016/j.jtbi.2018.02.008
http://crdd.osdd.net/open/2018/
 
Identifier Muthu Krishnan, S. (2018) Using Chou's general PseAAC to analyze the evolutionary relationship of receptor associated proteins (RAP) with various folding patterns of protein domains. Journal of Theoretical Biology, 445. pp. 62-74. ISSN 00225193