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Reinforcing the Functionality of Mononuclear Phagocyte System to Control Tuberculosis

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Reinforcing the Functionality of Mononuclear Phagocyte System to Control Tuberculosis
 
Creator Pahari, Susanta
Kaur, Gurpreet
Negi, Shikha
Aqdas, Mohammad
Das, Deepjyoti K.
Bashir, Hilal
Singh, Sanpreet
Nagare, Mukta
Khan, Junaid
Agrewala, J N
 
Subject QR Microbiology
 
Description The mononuclear phagocyte system (MPS) constitutes dendritic cells, monocytes, and macrophages. This system contributes to various functions that are essential for maintaining homeostasis, activation of innate immunity, and bridging it with the adaptive immunity. Consequently, MPS is highly important in bolstering immunity against the pathogens. However, MPS is the frontline cells in destroying Mycobacterium tuberculosis (Mtb), yet the bacterium prefers to reside in the hostile environment of macrophages. Therefore, it may be very interesting to study the struggle between Mtb and MPS to understand the outcome of the disease. In an event when MPS predominates Mtb, the host remains protected. By contrast, the situation becomes devastating when the pathogen tames and tunes the host MPS, which ultimately culminates into tuberculosis (TB). Hence, it becomes extremely crucial to reinvigorate MPS functionality to overwhelm Mtb and eliminate it. In this article, we discuss the strategies to bolster the function of MPS by exploiting the molecules associated with the innate immunity and highlight the mechanisms involved to overcome the Mtb-induced suppression of host immunity. In future, such approaches may provide an insight to develop immunotherapeutics to treat TB.
 
Publisher Frontiers Research Foundation
 
Date 2018-02-09
 
Type Article
PeerReviewed
 
Relation http://dx.doi.org/10.3389/fimmu.2018.00193
http://crdd.osdd.net/open/2019/
 
Identifier Pahari, Susanta and Kaur, Gurpreet and Negi, Shikha and Aqdas, Mohammad and Das, Deepjyoti K. and Bashir, Hilal and Singh, Sanpreet and Nagare, Mukta and Khan, Junaid and Agrewala, J N (2018) Reinforcing the Functionality of Mononuclear Phagocyte System to Control Tuberculosis. Frontiers in Immunology, 9. ISSN 1664-3224