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Computational Exploration of Putative LuxR Solos in Archaea and Their Functional Implications in Quorum Sensing

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Computational Exploration of Putative LuxR Solos in Archaea and Their Functional Implications in Quorum Sensing
 
Creator Rajput, Akanksha
Kumar, Manoj
 
Subject QR Microbiology
 
Description LuxR solos are unexplored in Archaea, despite their vital role in the bacterial regulatory network. They assist bacteria in perceiving acyl homoserine lactones (AHLs) and/or non-AHLs signaling molecules for establishing intraspecies, interspecies, and interkingdom communication. In this study, we explored the potential LuxR solos of Archaea from InterPro v62.0 meta-database employing taxonomic, probable function, distribution, and evolutionary aspects to decipher their role in quorum sensing (QS). Our bioinformatics analyses showed that putative LuxR solos of Archaea shared few conserved domains with bacterial LuxR despite having less similarity within proteins. Functional characterization revealed their ability to bind various AHLs and/or non-AHLs signaling molecules that involve in QS cascades alike bacteria. Further, the phylogenetic study indicates that Archaeal LuxR solos (with less substitution per site) evolved divergently from bacteria and share distant homology along with instances of horizontal gene transfer. Moreover, Archaea possessing putative LuxR solos, exhibit the correlation between taxonomy and ecological niche despite being the inhabitant of diverse habitats like halophilic, thermophilic, barophilic, methanogenic, and chemolithotrophic. Therefore, this study would shed light in deciphering the role of the putative LuxR solos of Archaea to adapt varied habitats via multilevel communication with other organisms using QS.
 
Publisher Frontiers Research Foundation
 
Date 2017
 
Type Article
PeerReviewed
 
Relation http://dx.doi.org/10.3389/fmicb.2017.00798
http://crdd.osdd.net/open/2068/
 
Identifier Rajput, Akanksha and Kumar, Manoj (2017) Computational Exploration of Putative LuxR Solos in Archaea and Their Functional Implications in Quorum Sensing. Frontiers in Microbiology, 8. ISSN 1664-302X