Record Details

Gleaning evolutionary insights from the genome sequence of a probiotic yeast Saccharomyces boulardii

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Gleaning evolutionary insights from the genome sequence of a probiotic yeast Saccharomyces boulardii
 
Creator Khatri, Indu
Akhtar, Akil
Kaur, Kamaldeep
Tomar, Rajul
Prasad, Gandham Satyanarayana
Ramya, Thirumalai Nallan Chakravarthy
Subramanian, Srikrishna
 
Subject QR Microbiology
 
Description BACKGROUND:
The yeast Saccharomyces boulardii is used worldwide as a probiotic to alleviate the effects of several gastrointestinal diseases and control antibiotics-associated diarrhea. While many studies report the probiotic effects of S. boulardii, no genome information for this yeast is currently available in the public domain.

RESULTS:
We report the 11.4 Mbp draft genome of this probiotic yeast. The draft genome was obtained by assembling Roche 454 FLX + shotgun data into 194 contigs with an N50 of 251 Kbp. We compare our draft genome with all other Saccharomyces cerevisiae genomes.

CONCLUSIONS:
Our analysis confirms the close similarity of S. boulardii to S. cerevisiae strains and provides a framework to understand the probiotic effects of this yeast, which exhibits unique physiological and metabolic properties.
 
Publisher BioMed Central
 
Date 2013
 
Type Article
PeerReviewed
 
Relation http://dx.doi.org/10.1186/1757-4749-5-30
http://crdd.osdd.net/open/2083/
 
Identifier Khatri, Indu and Akhtar, Akil and Kaur, Kamaldeep and Tomar, Rajul and Prasad, Gandham Satyanarayana and Ramya, Thirumalai Nallan Chakravarthy and Subramanian, Srikrishna (2013) Gleaning evolutionary insights from the genome sequence of a probiotic yeast Saccharomyces boulardii. Gut Pathogens, 5 (1). p. 30. ISSN 1757-4749