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Swelling and drug release kinetics of composite wound dressing

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Title Statement Swelling and drug release kinetics of composite wound dressing
 
Added Entry - Uncontrolled Name Agrawal, Anuja ; Delhi Technological University
Purwar, Roli ; Delhi Technological University
 
Uncontrolled Index Term Composite dressing; Cotton fabric; Drug release; Polyethylene glycol; Release exponent; Swelling degree; Wound dressing
 
Summary, etc. <span lang="EN-IN"><p style="text-align: justify;">The aim of this study is to analyze the swelling and drug release kinetics of composite wound dressing material in different <em>p</em>H buffer solutions, simulating the <em>p</em>H range of wounds. Composite dressing material is prepared by grafting polyacrylic acid-co-acrylamide hydrogel on the cotton fabric using polyethylene glycol as crosslinking agent. Results show maximum equilibrium swelling at pH 7.0. Swelling kinetics at <em>p</em>H 5.5 and <em>p</em>H 7.0 solutions follow first order kinetics model, while that at <em>p</em>H 8.5 solution follow second order kinetics model. The drug release kinetics of composite dressing is investigated at different <em>p</em>H using model drug Bovine serum albumin. Drug release kinetics follows Peppas model and drug is released by Fickian diffusion mechanism. The surface morphology of the composite dressing is analyzed by scanning electron microscopy. The pores of different size are observed at different <em>p</em>H. The drug release from composite dressing is directly influenced by swelling and pore size. These composite wound dressing materials have a great potential to be used as a medicated dressing in wound healing process for non chronic wounds.</p></span>
 
Publication, Distribution, Etc. Indian Journal of Fibre & Textile Research (IJFTR)
2018-04-09 12:51:21
 
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http://op.niscair.res.in/index.php/IJFTR/article/view/8452
 
Data Source Entry Indian Journal of Fibre & Textile Research (IJFTR); ##issue.vol## 43, ##issue.no## 1 (2018): Indian Journal of Fibre & Textile Research
 
Language Note en