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<p><strong><em></em></strong><em>In vitro</em> and <em>in vivo</em> pharmacological activities of the extracts of <em>Rheum nobile</em> Hook. f. & Thomson rhizomes</p>
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dc |
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| Title Statement |
<p><strong><em></em></strong><em>In vitro</em> and <em>in vivo</em> pharmacological activities of the extracts of <em>Rheum nobile</em> Hook. f. & Thomson rhizomes</p> |
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| Added Entry - Uncontrolled Name |
Gupta, Richa K.; Faculty of Science, Nepal Academy of Science and Technology (NAST), Khumaltar, Lalitpur, Nepal.
Central Department of Chemistry, Tribhuvan University, Kirtipur, Kathmandu, Nepal Bharati, Laxman ; Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal Shakya, Kul Shobha ; Natural Products Research Laboratory, Thapathali, Kathmandu, Nepal Regmi, Bal Mukunda ; Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal Bajracharya, Gan B.; Nepal Academy of Science and Technology (NAST) Jha, Ram Narayan ; Tri-Chandra Multiple Campus, Tribhuvan University, Kathmandu, Nepal |
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Natural product chemistry; Pharmacology Analgesic; Antibacterial; Antidiabetic; Antifertility; Anti-inflammatory; Himalayan rhubarb. |
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| Summary, etc. |
<p><em>Rheum nobile </em>Hook. f. & Thomson (family Polygonaceae) is extraordinary, unexploited, and vulnerable Himalayan rhubarb with high ethnomedicinal values. Traditionally in Nepal, its rhizomes are used to relieve pain, swelling, and in bone fractures. In this study, several<em> in vitro</em> and <em>in vivo</em> assays of the rhizome extracts were carried out. The hexane, dichloromethane, ethyl acetate and butanolic extracts obtained after fractionation of 95 % ethanolic extract showed potentially cytotoxicity against <em>Artemia salina</em> nauplii and antibacterial effect. The 80 % ethanolic extract displayed sedative effect in mice (ED<sub>50</sub>= 100.32 mg/kg). The same extract inhibited 66.60 and 81.49 % of acetic acid-induced writhes in mice at doses 250 and 400 mg/kg, respectively (<em>p</em> <0.0001). The extract could increase the reaction latency up to 774.59 % in the Eddy’s hot plate assay (<em>p</em> <0.0001). A high anti-inflammatory effect was observed in the Albumin-induced paw edema assay. The extract also exhibited hypoglycemic activity by lowering blood glucose level in normoglycemic rats, and antifertility activity in pregnant rats. CNS depressant and antifertility activities are observed for the first time in genus <em>Rheum</em>.</p> |
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| Publication, Distribution, Etc. |
Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)] 2018-05-03 14:37:13 |
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| Electronic Location and Access |
application/pdf http://op.niscair.res.in/index.php/IJNPR/article/view/14302 |
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| Data Source Entry |
Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 8, ##issue.no## 3 (2017): September 2017 |
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| Language Note |
en |
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