Record Details

<p><span style="font-size: small; font-family: times\ new\ roman, times;">Pharmacological evaluations of ethanol extract of <em>Ficus benghalensis</em> L. seeds for its antiulcer and antimicrobial efficacy</span></p>

Online Publishing @ NISCAIR

View Archive Info
 
 
Field Value
 
Authentication Code dc
 
Title Statement <p><span style="font-size: small; font-family: times\ new\ roman, times;">Pharmacological evaluations of ethanol extract of <em>Ficus benghalensis</em> L. seeds for its antiulcer and antimicrobial efficacy</span></p>
 
Added Entry - Uncontrolled Name VIMALA, G
F, Gricilda Shoba; PG and Research Department of Zoology, Voorhees College, Vellore
P, Pandikumar
E, Sukumar
Self-funding
 
Uncontrolled Index Term Acute oral toxicity; Antiulcer activity; Antioxidant activity; Antimicrobial activity; Ficus benghalensis seed extract
 
Summary, etc. To evaluate the gastroprotective effect and antimicrobial efficacy of the seeds of <em>Ficus benghalensis</em> L. Acute oral toxicity study was performed according to the OECD test guidelines and the antiulcer assay was performed using ethanol-induced gastric ulcer model in albino rats. The antimicrobial activity and HPTLC analysis were also performed. The seed extract did not show any sign of toxicity at a dose of 4000 mg/kg body weight. Reductions in the ulcer index and gastric acid volume with increase in the pH of the gastric fluid in extract treated rats proved antiulcer activity. Increased levels of endogenous antioxidant enzymes superoxide dismutase and catalase with a decrease in lipid peroxidation in the extract treated animals demonstrated its antioxidant effect. The zone of inhibition was extremely great for all the tested microorganisms. HPTLC chromatogram showed a total of 9 peaks at different <em>R<sub>f</sub></em> values and peak area at 366 nm whereas seven peaks were observed at 254 nm. The number of peaks indicates the presence of constituents in the extract. <br /> Pre-treatment with <em>F. benghalensis</em> seed extract showed significant antiulcer activity that might be attributed to its antioxidant potential.<em> F. benghalensis</em> showed significant activity against bacteria and fungi. The extract containing phytoconstituents must have contributed to its antimicrobial activity.
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2018-05-03 14:50:47
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJNPR/article/view/14211
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 8, ##issue.no## 4 (2017): December, 2017
 
Language Note en
 
Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJNPR/article/download/14211/42010
 
Terms Governing Use and Reproduction Note Authors who publish with IJNPR agree that once published copyright of the article will be transferred to the publisher, with the work simultaneously licensed under a Creative Commons Attribution-BY-NC-ND 4.0 International License.. that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. Except where otherwise noted, the Articles on this site are licensed underCreative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India