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<p class="TitleMain"><span style="font-family: times\ new\ roman, times; font-size: small;">Evaluation of acute, sub-acute toxicity and cardiac activity of processed borax</span></p>

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Title Statement <p class="TitleMain"><span style="font-family: times\ new\ roman, times; font-size: small;">Evaluation of acute, sub-acute toxicity and cardiac activity of processed borax</span></p>
 
Added Entry - Uncontrolled Name Sarkar, Prasanta Kumar; J. B. Roy State Ayurvedic Medical College & Hospital West Bengal University of Health Sciences, Kolkata
Prajapati, Pradeep K; Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar- 361008, Gujarat, India
Shukla, Vinay J; Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar- 361008, Gujarat, India
Ravishankar, Basavaiah ; SDM College of Ayurveda, Kuthpady, Udupi, Karnataka, India
 
Uncontrolled Index Term Ayurveda, Pharmacology
Ayurveda, Borax; Cardiac activity; ECG, LD50; Sub-acute toxicity
 
Summary, etc. <p class="Abstract">Borax is used in Ayurveda to treat various diseases like asthma, ulcer, and others, after removal of the water for crystallization. It causes toxicity when accumulated in the body, leads to vomiting, fatigue, and renal failure. The present study was carried out to evaluate the acute and the sub-acute toxicity and cardiac activity of processed borax in rats. Acute toxicity of processed borax was observed at the doses of 112.5, 225.0, 450.0, 900.0, and 1800.0 mg/kg. Processed borax solution at 22.5 and 112.5 mg/kg/day dose was administered for 30 consecutive days in sub-acute toxicity study. Cardiac activity of processed borax was studied by giving borax solution at 22.5 and 112.5 mg/kg/day dose for 30 days and taking ECG. In the acute toxicity test, the processed borax did not produce any deaths. The sub-acute treatment with the processed borax (22.5 and 112.5 mg/kg, n = 6/group) failed to induce serious alterations in almost all the parameters, except toxicity in kidney at 112.5 mg/kg. No change in ECG was observed in cardiac activity study. The LD<sub>50 </sub>of processed borax is above 1.8 mg/kg. It has no serious toxicity on sub-acute exposure and has no pathological intervention on heart in rats.</p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2018-05-03 14:50:47
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/13342
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 8, ##issue.no## 4 (2017): December, 2017
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJNPR/article/download/13342/38845
 
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