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<span style="font-size: medium;"><p class="TitleMain"><span style="font-family: times\ new\ roman, times; font-size: small;">Bioactive compounds from marine <em>Stachybotrys </em>sp. QL23</span></p></span>

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Title Statement <span style="font-size: medium;"><p class="TitleMain"><span style="font-family: times\ new\ roman, times; font-size: small;">Bioactive compounds from marine <em>Stachybotrys </em>sp. QL23</span></p></span>
 
Added Entry - Uncontrolled Name Razek, Ahmed S. Abdel; Organic and Bioorganic Chemistry Dept.
Awady, Mohamed El; Microbial Biotechnology Department, Genetic Engineering and Biotechnology Division National Research Centre Cairo, Egypt
Hassan, Amal Z; Chemistry of Natural Compounds Department, Pharmaceutical Industries Research Division National Research Centre Cairo, Egypt
Yassin, Faten Y; Chemistry of Natural Compounds Department, Pharmaceutical Industries Research Division National Research Centre, Cairo, Egypt
Asker, Mohsen ; Microbial Biotechnology Department, Genetic Engineering and Biotechnology Division National Research Centre Cairo, Egypt
Shaaban, Mohamed ; Chemistry of Natural Compounds Department, Pharmaceutical Industries Research Division National Research Centre Cairo, Egypt
National Research Centre (NRC), Dokki, Giza Egypt/ Bielefeld University, Bielefeld, Germany
 
Uncontrolled Index Term Bioactive compounds; Marine fungi; Stachybotrys sp; Structure elucidation; Taxonomy
 
Summary, etc. During our ongoing search for bioactive compounds from microorganisms, the marine fungus <em>Stachybotrys</em> sp. QL23 was isolated from a sediment sample collected from Qarun Lake, El Fayoum governorate, Egypt and biologically screened to produce bioactive compounds. The fungal extract showed moderate to high activity against Gram positive and Gram-negative bacteria assayed. The genotypic characterization of <em>Stachybotrys</em> sp QL23 has been deduced basically on its 18S rDNA gene sequencing. Pre-chemical studies of the strain extract using different chromatographic techniques afforded the major bioactive metabolites, ergosterol (1) and linoleic acid (2), and their chemical structures were assigned using 1D and 2D NMR and Spectroscopy and HR-EI mass spectrometry. In this article, we present the isolation and taxonomical characterization of the producing fungal strain, along with the study of antimicrobial activity of the strain extract and compounds 1-2 using a set of microorganisms. The study of the QL23 using cervix carcinoma cell line (KB-3-1) extract has been reported as well.
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2018-05-03 14:50:47
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/17067
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 8, ##issue.no## 4 (2017): December, 2017
 
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