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<p class="TitleMain"><span style="font-size: small; font-family: times\ new\ roman, times;">Protective effect of <em>Solanum torvum</em> on monosodium glutamate-induced neurotoxicity in mice</span></p>

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Title Statement <p class="TitleMain"><span style="font-size: small; font-family: times\ new\ roman, times;">Protective effect of <em>Solanum torvum</em> on monosodium glutamate-induced neurotoxicity in mice</span></p>
 
Added Entry - Uncontrolled Name Mohan, Mahalaxmi ; Priyadarshini College of Pharmaceutical Sciences, Chowdaryguda, Narapally, R.R. District, Hyderabad-500 094
Gangurde, Sushil Kumar
Kadam, Vrushali
 
Uncontrolled Index Term Excitotoxicity; Monosodium glutamate; Neurotoxicity; Oxidative stress; Solanum torvum
 
Summary, etc. <em>Solanum torvum</em> is a well known traditional herbal medicinal plant used in many neurological disorders. The objective of the study was to evaluate the effects of <em>S. torvum</em> on monosodium glutamate (MSG) induced neurotoxicity. Swiss albino mice received MSG (1000 mg/kg, p.o) followed by a methanolic and hydroalcoholic extract of <em>S. torvum</em>(100 and 300 mg/kg, p.o) for 14 days. MSG-treated mice showed significant (<em>p</em>&lt;0.05) behavioural changes, decrease in relative organ weight of brain, a decrease in antioxidant enzyme levels and significant (<em>p</em>&lt;0.05) increase in lipid peroxidation in brain tissue. Histopathological changes observed in brain tissue were vacuolated cells, pyknotic nuclei, decreased neuronal density and distorted layers of brain tissue. Both extracts of <em>S. torvum</em> (100 and 300 mg/kg) showed normal behavior, significant (<em>p</em>&lt;0.05) increase in relative organ weight of brain, significant (<em>p</em>&lt;0.05) decrease in lipid peroxidation (LPO) and significant (<em>p</em>&lt;0.05) increase in reduced glutathione (RGSH), superoxide dismutase (SOD) and catalase (CAT) concentration in brain tissue as compared to MSG-treated mice. Treatment with <em>S. torvum</em> extracts reversed the histopathological changes induced by MSG. The study suggests that <em>S. torvum</em> seed extracts have the potential to ameliorate neuronal damage induced by MSG. Total flavonoid content of methanolic and hydroalcoholic extract of <em>S. torvum</em> was found to be44±1.2,and32±0.8 µg of rutin equivalent/mg of extracts and total phenolic content was found to be 70±0.28 and 52±0.62 µg of gallic acid equivalent/mg of extracts respectively.
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2018-05-03 14:50:47
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/16551
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 8, ##issue.no## 4 (2017): December, 2017
 
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