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The composition of the essential oil and aqueous distillate of Origanum vulgare L. growing in Saudi Arabia and evaluation of their antibacterial activity

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Title The composition of the essential oil and aqueous
distillate of Origanum vulgare L. growing in Saudi
Arabia and evaluation of their antibacterial activity
 
Creator Khan, Merajuddin
Khan, Shams T.
Khan, Noor A
Mahmood, Adeem
Al-Kedhairy, Abdulaziz A.
Alkhathlan, Hamad Z.
 
Subject Biochemistry
 
Description The essential oil and aqueous distillate composition of Origanum vulgare L. were analyzed
by GC/MS. Sixty-seven different components were detected in both oils. Sixty-four components
were characterized for the oil derived from the aerial parts, whereas thirty-three
components in the volatile oil from the aqueous distillates of O. vulgare L., representing 99.8%
and 98.5% of the oils, respectively. The main components of the volatile oil from the aerial parts
of O. vulgare L. were carvacrol (70.2 ± 1.37%), c-terpinene (5.6 ± 0.11%), p-cymene (4.5 ± 0.42
%), trans-sabinene hydrate (3.8 ± 0.07%), and thymol (2.2 ± 0.12%). In comparison, the main
compounds of the volatile oil of the O. vulgare L. aqueous distillates were carvacrol (92.5 ± 0.97
%), thymol (2.5 ± 0.09%), and terpinen-4-ol (1.0 ± 0.03%). The antibacterial activity of both oils,
along with that of the purified major component, carvacrol, against Gram-positive and Gramnegative
strains was assessed. The results revealed that all three samples showed significant antibacterial
activity against all tested strains. The IC50 values of the oils derived from the aerial parts and
aqueous distillates of O. vulgare L. against the tested strains was in the range of 107–383 mg�mL1
,
whereas, the IC50 value of carvacrol was in the range of 53–151 mg�mL1
. The data suggest that carvacrol,
a major component of both oils, possesses the highest antibacterial activity of all the
 
Publisher Elsevier
 
Date 2018
 
Type Article
NonPeerReviewed
 
Format application/pdf
 
Identifier http://neeri.csircentral.net/1140/1/Noor%20Paper%20on%20Arabian%20journal%20of%20chemistry%202018.pdf
Khan, Merajuddin and Khan, Shams T. and Khan, Noor A and Mahmood, Adeem and Al-Kedhairy, Abdulaziz A. and Alkhathlan, Hamad Z. (2018) The composition of the essential oil and aqueous distillate of Origanum vulgare L. growing in Saudi Arabia and evaluation of their antibacterial activity. Arabian journal of chemistry. ISSN 1878-5352 (Submitted)
 
Relation https://www.sciencedirect.com/science/article/pii/S1878535218300479?via%3Dihub
http://neeri.csircentral.net/1140/