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| Field | Value |
| Title | Synthesis of Functionalized Pyrazoles via 1,3-Dipolar Cycloaddition of alpha-Diazo-beta-ketophosphonates, Sufones and Esters with Electron-Deficient Alkenes |
| Names |
BAIJU, TV
NAMBOOTHIRI, INN |
| Date Issued | 2017 (iso8601) |
| Abstract | 1,3-Dipolar cycloaddition of diazo compounds with olefinic substrates is a promising atom-economic strategy for the construction of functionalized pyrazoles. Over the last few years, our group has been engaged in the synthesis of phosphonyl/sulfonylpyrazoles and pyrazole esters by employing Bestmann-Ohira Reagent (BOR) and its sulfur and ester analogs as 1,3-dipole precursors with various dipolarophiles. This account describes the novel synthetic methods developed in our laboratory, in the perspective of closely related work by others, for the synthesis of phosphonyl/sulfonylpyrazoles, pyrazole esters and the total synthesis of Withasomnine, a natural product, by using 1,3-dipolar cycloaddition as the key step. |
| Genre | Review |
| Topic | BESTMANN-OHIRA REAGENT |
| Identifier | CHEMICAL RECORD,17(10)939-955 |