Record Details

Effect of Ultrasound on Neuronal Network Communication

Electronic Theses of Indian Institute of Science

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Field Value
 
Title Effect of Ultrasound on Neuronal Network Communication
 
Creator Popli, Divyaratan
 
Subject Neuronal Network Communication
Low Frequency Ultrasound
Inter Spike Intervals
Ultrasound Transducers
Ultrasound - Neuronal Activity
Neuronal Network Communication
Molecular Biophysics
 
Description Low intensity and low frequency ultrasound has been shown to modulate ion channel currents, membrane capacitive currents, and as a result, neuronal activity. Ultrasound has been used as a non-invasive way to modulate neuronal activity in vivo using mice as well as human subjects. Ultrasound with acoustic frequency as low as 0.35 MHz can be focussed on a region as small as 2 mm with reversible effects and no increase in temperature. In this study, two ultrasound transducers with different resonant frequency have been used to excite neuronal cultures. The resulting changes in the network properties such as synchronised network burst frequency, density, clustering and path length have been analysed. The study shows that ultrasound stimulation at acoustic frequency 450 kHz (ISPPA =11.3 mW/cm2) significantly modulates the above mentioned parameters and causes deviations from small world network properties of the control network.
 
Contributor Sikdar, Sujit Kumar
 
Date 2018-05-22T16:26:52Z
2018-05-22T16:26:52Z
2018-05-22
2017
 
Type Thesis
 
Identifier http://etd.iisc.ernet.in/2005/3589
http://etd.iisc.ernet.in/abstracts/4457/G28200-Abs.pdf
 
Language en_US
 
Relation G28200