Record Details

Modelling How Refractoriness to Interferon Compromises Interferon-Free Treatment of Hepatitis C Virus Infection

Electronic Theses of Indian Institute of Science

View Archive Info
 
 
Field Value
 
Title Modelling How Refractoriness to Interferon Compromises Interferon-Free Treatment of Hepatitis C Virus Infection
 
Creator Venugopal, Vishnu
 
Subject HCV Lifecycle
Hepatitis C Virus Infection
Multiple Loci
DAA Based Treatment
RAVs
HCV Kinetics
Direct Acting Antivirals (DAAs)
Interferon-Free Treatment
Chemical Engineering
 
Description Hepatitis C virus (HCV) infection globally affects 130-150 million people. It causes both acute and chronic infections. Due to the severe side effects and low success rates of interferon based treatments, which formed the standard treatment for HCV, the treatment paradigm shifted to direct acting antivirals (DAAs).
DAAs have revolutionized the treatment of hepatitis C virus infection. Clinical trials with combinations of DAAs have recorded >90% response with shorter treatment durations and fewer side effects than earlier treatments involving IFN. Outside the controlled setting of a clinical trial, however, response rates with DAA combinations are much lower (
 
Contributor Dixit, Narendra
 
Date 2018-05-25T05:30:48Z
2018-05-25T05:30:48Z
2018-05-25
2017
 
Type Thesis
 
Identifier http://etd.iisc.ernet.in/2005/3612
http://etd.iisc.ernet.in/abstracts/4481/G28483-Abs.pdf
 
Language en_US
 
Relation G28483