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Biodegradable Polymers for Drug Delivery and Tissue Engineering

Electronic Theses of Indian Institute of Science

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Field Value
 
Title Biodegradable Polymers for Drug Delivery and Tissue Engineering
 
Creator Natarajan, Janeni
 
Subject Drug Delivery
Biodegradable Polymers
Tissue Engineering
Poly (ethylene erephthalate)
Castor Oil Sebacic Acid
Biodegradable Polymers
Polyanhydrides
Maltitol
Galactitol Polyester Elastomers
Poly (ester amide)s
Epoxidized Soybean Oil (ESO)
Poly (Galactitol Sebacate)
Bone Tissue Engineering
Galactitol
Nanoscience
 
Description Regeneration, a spontaneous response of bones in response to injuries, infections and fractures, is severely compromised in certain clinical circumstances. Unfortunately, several shortcomings are associated with the current treatment of bone grafting method such as donor shortage and immune response for allografts and donor morbidity for autografts. Thus, the development of clinical alternates is essential. One promising adjunct method is bone tissue engineering that includes the implantation of a scaffold containing the cells with the supplementation of suitable growth factors. Among the various classes of materials, biodegradable polymers are commonly preferred because their use does not necessitate a secondary surgery for their removal after the intended use. Commercially available polymers such as poly (lactic- co- glycolic acid) and polycaprolactone are expensive and degrade slowly. This motivates the development of novel synthetic biodegradable polymers that are affordable and can be tuned to tailor for specific biomedical applications.
The primary aim of this thesis is to synthesize effective biodegradable polymers for drug delivery and bone tissue engineering. The properties of these polymers such as modulus, hydrophobicity and crosslinking etc. were tailored based on the variations in chemical bonds, chain lengths and the molar stoichiometric ratios of the monomers for specific clinical applications. Based on the above variations, degradation and release kinetics were tuned. The cytocompatibilty properties for these polymers were studied and suitable mineralization studies were conducted to determine their potential for bone regeneration.
 
Contributor Madras, Giridhar
 
Date 2018-06-29T07:52:34Z
2018-06-29T07:52:34Z
2018-06-29
2017
 
Type Thesis
 
Identifier http://etd.iisc.ernet.in/2005/3776
http://etd.iisc.ernet.in/abstracts/4647/G28515-Abs.pdf
 
Language en_US
 
Relation G28515