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<p style="text-align: justify;">GC–MS analysis of essential oil of <em>Pinus roxburghii</em> Sarg. (Chir pine) needles and evaluation of antibacterial and anti-proliferative properties</p>

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Title Statement <p style="text-align: justify;">GC–MS analysis of essential oil of <em>Pinus roxburghii</em> Sarg. (Chir pine) needles and evaluation of antibacterial and anti-proliferative properties</p>
 
Added Entry - Uncontrolled Name Bhagat, Madhulika ; University of Jammu
Bandral, Anuj ; University of Jammu
Bashir, Mudassar ; University of Jammu
Bindu, Kushal ; CSIR-Indian Institute of Integrative Medicine
Cancer Pharmacology Division, IIIM-CSIR Jammu
 
Uncontrolled Index Term Antibacterial; Cytotoxic; Essential oil; Needles; Pinus roxburghii
 
Summary, etc. <p style="text-align: justify;">The present study was carried out to analyse the biological properties and chemical composition by GC-MS analysis of the essential oil of the needles of<em> Pinus roxburghii</em>. Sixteen components were identified from their fragmentation pattern in the essential oil. Major component present in the essential oil belonged to monoterpene (84.38 %), oxygenated monoterpene (4.23 %) and Sesquiterperne (11.35 %) category. The antibacterial potential was analysed by paper disc diffusion assay against 5 gram-positive bacteria and 5 gram-negative bacteria. Oil showed a broad spectrum of activity by inhibiting all the 5 gram-positive bacteria and 2 gram-negative bacteria viz., <em>Escherichia coli</em> and <em>Campylobacter coli</em>. The antiproliferative property was measured against A-549 (lung), T98G (glioblastoma), PC-3 (prostate) and T47D (breast) human cancer cell lines by Sulphorhodamine-B assay. Here, the essential oil exhibited cytotoxic properties against human cancer cell lines with IC<sub>50 </sub>values of 161.30 μg/mL and 154.30 μg/mL for A549 and T98G respectively.<strong> </strong>The results suggest that active component of the essential oil of <em>Pinus roxburghii</em> possess antimicrobial and antiproliferative properties which may be useful for food preservation, pharmaceutical treatment and natural therapies.</p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2018-07-23 08:37:15
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/2110
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 9, ##issue.no## 1 (2018): March, 2018
 
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