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Matrix Metalloproteinases in Health and Disease: Regulation by Melatonin

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Title Matrix Metalloproteinases in Health and Disease: Regulation by
Melatonin
 
Creator Swarnakar, Snehasikta
Paul, Sumit
Singh, Laishram Pradeepkumar
Reiter, Russel J
 
Subject Drug Development/Diagnostics & Biotechnology
 
Description Matrix metalloproteinases (MMPs) are part of a superfamily of
metal-requiring proteases that play important roles in tissue remodeling by
breaking down proteins in the extracellular matrix that provides structural
support for cells. The intricate balance in protease/anti-protease
stoichiometry is a contributing factor in a number of diseases. Melatonin
possesses multifunctional bioactivities including antioxidative, antiin
.ammatory, endocrinologic and behavioral e.ects. As melatonin a.ects
the redox status of tissues, the association of reactive oxygen species (ROS)
with tissue injury under di.erent circumstances may be mitigated by
melatonin. Redox signaling is expanding into all areas of basic and clinical
sciences, and this timely review focuses on the topic of regulation of MMP
activities by melatonin. This is a rapidly growing .eld. Accumulating
evidence indicates that oxidative stress plays an important role in regulating
the activities of MMPs that are involved in various cellular processes such as
cellular proliferation, angiogenesis, apoptosis, invasion and metastasis. This
review o.ers sections on MMPs, melatonin, major physiological and
pathophysiological conditions in the context to MMPs, followed by redox
signaling mechanisms that are known to in.uence the cellular processes.
Finally, we discuss the emerging molecular mechanisms relevant to
regulatory actions of melatonin on the activities of MMPs. The possibility
that melatonin might have therapeutic signi.cance via regulation of MMPs
may be a novel approach in the treatment of some diseases.
 
Date 2011
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/63/1/JOURNAL_OF_PINEAL_RESEARCH%2C50(1)%2C8%2D20%2C2011[98].pdf
Swarnakar, Snehasikta and Paul, Sumit and Singh, Laishram Pradeepkumar and Reiter, Russel J (2011) Matrix Metalloproteinases in Health and Disease: Regulation by Melatonin. Journal of Pineal Research, 50 (1). pp. 8-20.
 
Relation http://dx.doi.org/10.1111/j.1600-079X.2010.00812.x
http://www.eprints.iicb.res.in/63/