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Melatonin promotes angiogenesis during protection and healing of indomethacin-induced gastric ulcer: role of matrix metaloproteinase-2

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Title Melatonin promotes angiogenesis during protection and healing of
indomethacin-induced gastric ulcer: role of matrix
metaloproteinase-2
 
Creator Ganguly, Krishnendu
Sharm, Anamika Vivek
Reiter, Russel J
Swarnakar, Snehasikta
 
Subject Drug Development/Diagnostics & Biotechnology
 
Description Matrix metalloproteinase (MMP)-2 is considered as a crucial
regulator of angiogenesis, a process of new blood vessel formation. We
reported previously that melatonin (N-acetyl-5-methoxy tryptamine), an
antioxidant and anti-inflammatory agent, prevents indomethacin-induced
gastric ulcers. Herein, we investigated the effect of melatonin on MMP-2-
mediated angiogenesis during gastroprotection. Angiogenic properties of
melatonin were tested in both rat corneal micropocket assay and in mouse
model of indomethacin-induced gastric lesions. Melatonin augmented
angiogenesis that was associated with amelioration of MMP-2 expression
and activity and, upregulation of vascular endothelial growth factor (VEGF)
in rat cornea. Melatonin prevented gastric lesions by promoting angiogenesis
via upregulation of VEGF followed by over-expression ofMMP-2. Similarly,
healing of gastric lesions was associated with early expression of VEGF
followed by MMP-2. In addition, upregulation of MMP-2 was parallel to
MMP-14 and inverse to tissue inhibitor of metalloprotease (TIMP)-2
expression during gastroprotection. Our data demonstrated that melatonin
exerts angiogenesis through MMP-2 and VEGF over-expression during
protection and healing of gastric ulcers. This study highlights for the first
time a phase-associated regulation of MMP-2 activity in gastric mucosa and
an angiogenic action of melatonin to rescue indomethacin-induced
gastropathy.
 
Date 2010
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/90/1/JOURNAL_OF_PINEAL_RESEARCH_49(2)130%2D140;2010[38].pdf
Ganguly, Krishnendu and Sharm, Anamika Vivek and Reiter, Russel J and Swarnakar, Snehasikta (2010) Melatonin promotes angiogenesis during protection and healing of indomethacin-induced gastric ulcer: role of matrix metaloproteinase-2. Journal of Pineal Research, 49 (2). pp. 130-140.
 
Relation http://dx.doi.org/10.1111/j.1600-079X.2010.00776.x
http://www.eprints.iicb.res.in/90/