Record Details

UDP-Gal: N-acetylglucosamine β 1–4 galactosyltransferase expressing live attenuated parasites as vaccine for visceral leishmaniasis

EPrints@IICB

View Archive Info
 
 
Field Value
 
Title UDP-Gal: N-acetylglucosamine β 1–4 galactosyltransferase
expressing live attenuated parasites as vaccine
for visceral leishmaniasis
 
Creator Bhaumik, Siddhartha Kumar
Singh, Manoj Kumar
Karmakar, Subir
De, Tripti
 
Subject Infectious Diseases and Immunology
 
Description As compared to cutaneous leishmaniasis, vaccination
against visceral leishmaniasis (VL) has received
limited attention. In this study, we demonstrate for the first
time that an UDP-Galactose: N-acetylglucosamine β 1–4
galactosyltransferase (GenBank Accession No. EF159943)
expressing attenuated LD clonal population (A-LD) is able
to confer protection against the experimental challenge with
the virulent LD AG83 parasite. A-LD was also effective in
established leishmania infection. The vaccinated animals
showed both cell mediated (in vitro T-cell proliferation, and
DTH response) and humoral responses (Th1 type). These
results demonstrate the potential of the attenuated clones as
an immunotherapeutic and immunoprophylactic agent
against visceral leishmaniasis.
 
Publisher Kluwer
 
Date 2009
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/171/1/GLYCOCONJUGATE_JOURNAL%2C_26(6)%2C_663%2D673%2C2009[40].pdf
Bhaumik, Siddhartha Kumar and Singh, Manoj Kumar and Karmakar, Subir and De, Tripti (2009) UDP-Gal: N-acetylglucosamine β 1–4 galactosyltransferase expressing live attenuated parasites as vaccine for visceral leishmaniasis. Glycoconjugate Journal, 26. pp. 663-673.
 
Relation http://dx.doi.org/10.1007/s10719-008-9212-y
http://www.eprints.iicb.res.in/171/