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Taurine Fails to Protect Against 1-methyl-4-phenyl-1,2,3,6- Tetrahydropyridine-Induced Striatal Dopamine Depletion in Mice

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Title Taurine Fails to Protect Against 1-methyl-4-phenyl-1,2,3,6-
Tetrahydropyridine-Induced Striatal Dopamine Depletion in Mice
 
Creator Navneet, A K
Appukuttan, T A
Pandey, M
Mohanakumar, K P
 
Subject Cell Biology & Physiology
 
Description The potent parkinsonian neurotoxin, 1-methyl-4-phenyl-
1,2,3,6-tetrahydropyridine (MPTP) through its oxidized
metabolite, 1-methyl-4-phenylpyridinium (MPPþ) causes
lesion specifically to the dopaminergic system of the substantia nigra pars compacta (SNpc) of the brain (Burns
et al., 1983). This ability of MPTP and MPPþ has been
exploited to develop animal models for Parkinson’s disease
(PD). MPTP crosses the blood–brain barrier, gets converted
to its neurotoxically active metabolite MPPþ by
monoamine oxidase-B in astrocytes and is selectively taken
up into dopaminergic neurons by dopamine (DA) transporters
(Javitch et al., 1985; Ransom et al., 1987), where
it is sequestered into the mitochondria (Ramsay and Singer,
1986). MPPþ causes mitochondrial complex I inhibition,
leading to an out surge of free radical species as the lethal process in the neuronal death (Tieu et al., 2003).
 
Date 2008
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/179/1/AMINO_ACIDS%2C_35(2)%2C_457%2D461%2C2008[49].pdf
Navneet, A K and Appukuttan, T A and Pandey, M and Mohanakumar, K P (2008) Taurine Fails to Protect Against 1-methyl-4-phenyl-1,2,3,6- Tetrahydropyridine-Induced Striatal Dopamine Depletion in Mice. Amino Acids, 35 (2). pp. 457-461.
 
Relation http://dx.doi.org/10.1007/s00726-007-0571-7
http://www.eprints.iicb.res.in/179/