Record Details

Oxidation of hemoglobin and redistribution of band 3 promote erythrophagocytosis in visceral leishmaniasis

EPrints@IICB

View Archive Info
 
 
Field Value
 
Title Oxidation of hemoglobin and redistribution of band 3 promote
erythrophagocytosis in visceral leishmaniasis
 
Creator Saha Roy, Sudipa
Dutta Chowdhury, Kaustav
Sen, Gargi
Biswas, Tuli
 
Subject Cell Biology & Physiology
 
Description In visceral leishmaniasis (VL), oxidative
assault on erythrocytes perturbs their cellular environment
and makes them vulnerable to premature hemolysis. In this
study, we assessed the contribution of oxidation-induced
modifications of hemoglobin and membrane protein band 3
in the reduced survival of red cells in VL. Oxidative
transformation of oxyhemoglobin to hemichrome enhanced
its interaction with erythrocyte membrane in the infected
animals. Association between denatured globin and band 3
contributed to the formation of insoluble copolymer of
macromolecular dimension. Disulfide bonding appeared to
be necessary in the making of high molecular weight
aggregates during copolymerization. Hemichrome induced
clustering of band 3 promoted generation of epitopes on
erythrocyte cell surface. This provided a signal favoring
immunologic recognition of redistributed band 3 by
autologous IgG followed by erythrophagocytosis. An
eventual outcome of the sequence of events pointed to
early removal of affected red cells from circulation during
the disease.
 
Publisher Kluwer
 
Date 2009
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/235/1/MOLECULAR_AND_CELLULAR_BIOCHEMISTRY%2C321(_1%2D2)%2C53%2D63%2C2009[128].pdf
Saha Roy, Sudipa and Dutta Chowdhury, Kaustav and Sen, Gargi and Biswas, Tuli (2009) Oxidation of hemoglobin and redistribution of band 3 promote erythrophagocytosis in visceral leishmaniasis. Molecular and Cellular Biochemistry, 321 (1-2). pp. 53-63.
 
Relation http://dx.doi.org/10.1007/s11010-008-9909-z
http://www.eprints.iicb.res.in/235/