Record Details

Stearylamine-Bearing Cationic Liposomes Kill Leishmania parasites through Surface Exposed Negatively Charged Phosphatidylserine

EPrints@IICB

View Archive Info
 
 
Field Value
 
Title Stearylamine-Bearing Cationic Liposomes Kill Leishmania parasites through Surface Exposed Negatively Charged Phosphatidylserine
 
Creator Banerjee, Antara
Roychoudhury, Jayeeta
Ali, Nahid
 
Subject Infectious Diseases and Immunology
 
Description Leishmania parasites are the causative agents for cutaneous and visceral leishmaniasis (VL) with �2 million cases annually and a prevalence rate of 12 million, respectively. VL, principally caused by Leishmania donovani, is fatal if left untreated.1 Pentavalent antimonials, though toxic, remain the first-line drugs for leishmaniasis. Emergence of drug resistance has pushed in second-line drugs such as amphotericin B and pentamidine, which cause toxic side effects.2–4 Miltefosine, the most recent oral drug for VL, is potentially teratogenic.2 Moreover, clinical
trials have identified occasional gastrointestinal toxicity that requires treatment withdrawal
 
Date 2008
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/238/1/JOURNAL_OF_ANTIMICROBIAL_CHEMOTHERAPY%2C61(1)%2C103%2D110%2C2008[145].pdf
Banerjee, Antara and Roychoudhury, Jayeeta and Ali, Nahid (2008) Stearylamine-Bearing Cationic Liposomes Kill Leishmania parasites through Surface Exposed Negatively Charged Phosphatidylserine. Journal of Antimicrobial Chemotherapy, 61 (1). pp. 103-110.
 
Relation http://dx.doi.org/10.1093/jac/dkm396
http://www.eprints.iicb.res.in/238/