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Sphingolipid-mediated restoration of Mitf expression and repigmentation in vivo in a mouse model of hair graying

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Title Sphingolipid-mediated restoration of Mitf expression
and repigmentation in vivo in a mouse model of hair
graying
 
Creator Saha, Bidisha
Singh, Suman Kumar
Mallick, Shampa
Bera, Rabindranath
Datta, Pijush K
Mandal, Mriganka
Roy, Syamal
Bhadra, Ranjan
 
Subject Infectious Diseases and Immunology
Structural Biology & Bioinformatics
 
Description Recent advances in the identification and characterisation of stem cell populations has led to substantial interest
in understanding the precise triggers that would operate to induce activation of quiescent stem cells.
Melanocyte stem cells (MSCs) reside in the bulge region of the hair follicles and are characterised by reduced
expression of the microphthalmia-associated transcription factor (Mitf) and its target genes implicated in
differentiation. Vitiligo is characterised by progressive destruction of differentiated melanocytes. However,
therapies using UV irradiation therapy can induce a degree of repigmentation, suggesting that MSCs may be
activated. As Mitf is implicated in control of proliferation, we have explored the possibility that inducing Mitf
expression via lipid-mediated activation of the p38 stress-signalling pathway may represent a re-pigmentation
strategy. Here we have isolated from placental extract a C18:0 sphingolipid able to induce Mitf and tyrosinase
expression via activation of the p38 stress-signalling pathway. Strikingly, in age-onset gray-haired C57BL ⁄ 6J
mice that exhibit decaying Mitf expression, topical application of placental sphingolipid leads to increased
Mitf in follicular melanocytes and fresh dense black hair growth. The results raise the possibility that lipidmediated
activation of the p38 pathway may represent a novel approach to an effective vitiligo therapy
 
Date 2009
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/255/1/PIGMENT_CELL_%26_MELANOMA_RESEARCH%2C22(2)_%2C205%2D218%2C_2009[87].pdf
Saha, Bidisha and Singh, Suman Kumar and Mallick, Shampa and Bera, Rabindranath and Datta, Pijush K and Mandal, Mriganka and Roy, Syamal and Bhadra, Ranjan (2009) Sphingolipid-mediated restoration of Mitf expression and repigmentation in vivo in a mouse model of hair graying. Pigment Cell Melanoma Research, 22 (2). pp. 205-218.
 
Relation http://dx.doi.org/10.1111/j.1755-148X.2009.00548.x
http://www.eprints.iicb.res.in/255/