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Interaction of Isoquinoline Alkaloids with Polymorphic DNA Structures

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Title Interaction of Isoquinoline Alkaloids with Polymorphic DNA Structures
 
Creator Bhadra, Kakali
Maiti, Motilal
Kumar, G Suresh
 
Subject Chemistry
 
Description was studied. Berberine and palmatine showed moderate binding to the B form, while coralyne showed
higher binding, as revealed from spectroscopic and thermodynamic data. Berberine and coralyne binding
to the B form was exothermic and enthalpy-driven, while palmatine showed exothermic binding which
was favored by both negative enthalpy and negative entropy changes. Berberine and palmatine neither
bind nor converted the Z-form structure to B form. Coralyne, on the other hand, exhibited a strong
binding affinity to Z DNA structure that was enthalpy-driven. Berberine binding to the HL form was
cooperative, exothermic, and favored by both negative enthalpy and negative entropy changes with the
formation of an induced CD band. Palmatine showed weak binding, while coralyne showed a strong
binding with the HL form. The structural differences in the isoquinoline alkaloids appear to influence the
affinity and mode of interactions with these polymorphic DNA structures
 
Date 2009
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/257/1/JOURNAL_OF_GENETICS%2C88(4)%2C451%2D467%2C2009[3].pdf
Bhadra, Kakali and Maiti, Motilal and Kumar, G Suresh (2009) Interaction of Isoquinoline Alkaloids with Polymorphic DNA Structures. Chemistry & Biodiversity, 6 (9). pp. 1323-1342.
 
Relation http://dx.doi.org/ 10.1002/cbdv.200900017
http://www.eprints.iicb.res.in/257/