Record Details

Excess of Glucocorticoid Induces Cardiac Dysfunction via Activating Angiotensin II Pathway

EPrints@IICB

View Archive Info
 
 
Field Value
 
Title Excess of Glucocorticoid Induces Cardiac
Dysfunction via Activating Angiotensin II Pathway
 
Creator Ghose Roy, Sreerupa
De, Priyanka
Mukherjee, Debasri
Chander, Vivek
Konar, Aditya
Bandyopadhyay, Debasish
Bandyopadhyay, Arun
 
Subject Cell Biology & Physiology
 
Description Background: Glucocorticoid is widely used as an
anti-inflammatory drug in various diseases however
excess of it often causes cardiovascular
complications. The present study was undertaken to
understand the molecular mechanism of
glucocorticoid-induced cardiac dysfunction. Methods:
Rats were treated daily with synthetic glucocorticoid,
dexamethasone with or without mifepristone or
losartan up to 15 days. Hemodynamic parameters
were measured by PV-loop method using Millar’s
instrument. Cardiac remodelling, fibrosis and oxidative
stress were monitored after 15 days. Results: The
systolic blood pressure was increased whereas the
heart beat and cardiac output (n=6) were decreased
by dexamethasone. Dexamethasone caused increase
in the heart weight to body weight ratio (P
 
Publisher Karger
 
Date 2009
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/258/1/CELLULAR_PHYSIOLOGY_AND_BIOCHEMISTRY%2C_24(1%2D2)%2C1%2D10%2C2009[131].pdf
Ghose Roy, Sreerupa and De, Priyanka and Mukherjee, Debasri and Chander, Vivek and Konar, Aditya and Bandyopadhyay, Debasish and Bandyopadhyay, Arun (2009) Excess of Glucocorticoid Induces Cardiac Dysfunction via Activating Angiotensin II Pathway. Cellular Physiology and Biochemistry, 24 (1-2). 01-10.
 
Relation http://dx.doi.org/10.1159/000227803
http://www.eprints.iicb.res.in/258/