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Supramolecular Architecture in an Oxovanadium(V)-Schiff Base Complex: Synthesis, Ab initio Structure Determination from X-ray Powder Diffraction, DNA Binding and Cleavage Activity

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Title Supramolecular Architecture in an Oxovanadium(V)-Schiff Base
Complex: Synthesis, Ab initio Structure Determination from X-ray
Powder Diffraction, DNA Binding and Cleavage Activity
 
Creator Mondal, Swastik
Mukherjee, Monika
Dhara, Koushik
Ghosh, Soumen
Ratha, Jagnyeswar
Banerjee, Pradyot
Mukherjee, Alok K.
 
Subject Chemistry
 
Description The synthesis, spectroscopic characterization, X-ray powder structure determination, and thermal behavior of a binuclear
bis(í-oxo)-bridged vanadium(V) complex, [(VO2L)2], L ) N,N¢-dimethylenediamine(o-hydroxyl acetophenon), along with its DNA
binding ability and photoinduced DNA cleavage activity, have been described. The compound crystallizes in a monoclinic system
with a ) 7.679(3) Å, b ) 12.020(5) Å, c ) 13.882(6) Å, â ) 90.799(4)°, space group P21/c, and Z ) 2. The crystal structure has
been solved from laboratory X-ray powder diffraction data using the direct space approach and refined by the Rietveld method. The
dimeric complex consists of two edge-sharing vanadium octahedra with each metal center coordinated to one oxo-, one phenolate-,
and two bridging-oxygen ligands, and two nitrogen donor atoms. The molecular structure reveals a two-dimensional grid of R4 4 (24)
rings in the (011) plane, which on combination with one-dimensional polymeric chains along the [100] direction, forms a novel
three-dimensional supramolecular framework. Thermogravimetric analysis of the complex indicates multiple overlapping decomposition
steps in the temperature range 180-800 °C with the end product being V2O5. The complex binds to double-stranded DNA giving
a Kapp value of 1.56 � 107 M-1 and displays DNA cleavage activity on UV (300 nm) irradiation via a mechanistic pathway involving
formation of singlet oxygen as the reactive species.
 
Date 2007
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/264/1/CRYSTAL_GROWTH_%26_DESIGN%2C7(9)%2C1716%2D1721%2C2007[36].pdf
Mondal, Swastik and Mukherjee, Monika and Dhara, Koushik and Ghosh, Soumen and Ratha, Jagnyeswar and Banerjee, Pradyot and Mukherjee, Alok K. (2007) Supramolecular Architecture in an Oxovanadium(V)-Schiff Base Complex: Synthesis, Ab initio Structure Determination from X-ray Powder Diffraction, DNA Binding and Cleavage Activity. Crystal Growth & Design, 7 (9). pp. 1716-1721.
 
Relation http://dx.doi.org/10.1021/cg060753i CCC: $37.00
http://www.eprints.iicb.res.in/264/