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Role of Peritoneal Macrophages and Lymphocytes in the Development of Hypogonadal Osteoporosis in an Ovariectomized Rat Model: Possible Phytoestrogenic Efficacy of Oil Extract of Garlic to Preserve Skeletal Health

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Title Role of Peritoneal Macrophages and Lymphocytes in the Development of Hypogonadal Osteoporosis in an Ovariectomized Rat Model: Possible
Phytoestrogenic Efficacy of Oil Extract
of Garlic to Preserve Skeletal Health
 
Creator Mukherjee, M
Das, A S
Das, D
Mukherjee, S
Mitra, S
Mitra, C
 
Subject Drug Development/Diagnostics & Biotechnology
 
Description This study was to examine whether skeletal health deterioration in the hypogonadal situation is a consequence
of an alteration in the functional status of peripheral mononuclear cells and its amelioration, if any, by an oil
extract of garlic. The results suggest that hypogonadism-induced oxidative stress of peritoneal macrophages
and lymphocytes could be reduced by supplementation with an oil extract of garlic. However, estrogen
deficiency did not cause any significant change in DNA fragmentation of peritoneal macrophages. The
hypogonadism-induced increase in the serum levels of IL-6 and TNF- α were significantly reduced by an oil
extract of garlic. Further, such supplementation could revive the hypogonadism-induced decrease in serum
estrogen titer and counter-balance the increase in bone turnover as determined by low bone tensile strength
and alterations in bone related biochemical variables such as urinary calcium, hydroxyproline, calcium to
creatinine ratio and serum tartrate resistant acid phosphatase activity (TRAP). The garlic oil supplemented
partial recovery of the serum estrogen titer in hypogonadal rats was found to be persistently associated with
reduced oxidative stress of peritoneal macrophages and lymphocytes, reduced serum interleukins and better
preservation of bone mass. This study proposes that the hypogonadism-induced bone loss has a direct correlation
with the functional status of lymphocytes and peritoneal macrophages, and garlic can prevent this.
Copyright © 2007 John Wiley & Sons, Ltd.
 
Date 2007
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/272/1/PHYTOTHERAPY_RESEARCH%2C_21(11)%2C_1045%2D1054%2C2007%2C_[23].pdf
Mukherjee, M and Das, A S and Das, D and Mukherjee, S and Mitra, S and Mitra, C (2007) Role of Peritoneal Macrophages and Lymphocytes in the Development of Hypogonadal Osteoporosis in an Ovariectomized Rat Model: Possible Phytoestrogenic Efficacy of Oil Extract of Garlic to Preserve Skeletal Health. PHYTOTHERAPY RESEARCH, 21 (11). pp. 1045-1054.
 
Relation http://www.eprints.iicb.res.in/272/