ICAR Research Data Repository for Knowledge Management
Oral Therapy with Amlodipine and Lacidipine, 1,4-Dihydropyridine Derivatives Showing Activity against Experimental Visceral Leishmaniasis
EPrints@IICB
View Archive Info| Field | Value | |
| Title |
Oral Therapy with Amlodipine and Lacidipine, 1,4-Dihydropyridine Derivatives Showing Activity against Experimental Visceral Leishmaniasis |
|
| Creator |
Palit, Partha
Ali, Nahid |
|
| Subject |
Infectious Diseases and Immunology
|
|
| Description |
Amlodipine and lacidipine, conventional antihypertensive drugs, inhibited Leishmania donovani infection in vitro and in BALB/c mice when administered orally. These 1,4-dihydropyridine derivatives functioned through dose-dependent inhibition of oxygen consumption, triggering caspase 3-like activation-mediated programmed cell death of the parasites. |
|
| Date |
2008
|
|
| Type |
Article
PeerReviewed |
|
| Format |
application/pdf
|
|
| Identifier |
http://www.eprints.iicb.res.in/278/1/ANTIMICROBIAL_AGENTS_AND_CHEMOTHERAPY%2C52_(1)_374%2D377%2C_2008_[147].pdf
Palit, Partha and Ali, Nahid (2008) Oral Therapy with Amlodipine and Lacidipine, 1,4-Dihydropyridine Derivatives Showing Activity against Experimental Visceral Leishmaniasis. Antimicrobial Agents And Chemotherapy, 52 (1). pp. 374-377. |
|
| Relation |
http://dx.doi.org/10.1128/AAC.00522-07
http://www.eprints.iicb.res.in/278/ |
|