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DNA Repair Deficiency Leads to Susceptibility to Develop Arsenic-Induced Premalignant Skin Lesions

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Title DNA Repair Deficiency Leads to Susceptibility to Develop Arsenic-Induced Premalignant Skin Lesions
 
Creator Banerjee, Mayukh
Sarma, Nilendu
Biswas, Rupanwita
Roy, Jyoeeta
Mukherjee, Anita
Giri, Ashok K
 
Subject Molecular & Human Genetics
 
Description In West Bengal, India, although more than 6 million people are exposed to arsenic through drinking water, only 15–20% showed arsenic-induced skin lesions, including premalignant hyperkeratosis. This indicates toward some factors that confer susceptibility to arsenic-induced carcinogenicity. In this work, we wanted to explore whether differences in DNA repair capacity could impart arsenic-induced carcinogenicity, through Comet assay, chromosomal
aberration (CA) assay and challenge assay. Sixty arsenic
exposed (30 individuals with arsenic-induced premalignant hyperkeratosis and 30 without skin lesion, but drinking similar arsenic contaminated water) and 30 arsenic unexposed individuals were recruited as study participants. Alkaline comet assay, and challenge assay were carried out in whole blood and CA study in lymphocytes
to find out the DNA damage and DNA repair capacity in
both hyperkeratotic and without skin lesion individuals. DNA
damage as well as CA were found to be significantly higher in the arsenic-exposed individuals compared to unexposed individuals (p < 0.001). Within the exposed group, there was no significant difference as far as the level of DNA damage is concerned (p > 0.05), but CA was significantly higher in exposed individuals with hyperkeratosis
than exposed individuals without hyperkeratosis (p
 
Date 2008
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/289/1/INTERNATIONAL_JOURNAL_OF_CANCER%2C_123(_2)%2C283%2D287%2C2008[51].pdf
Banerjee, Mayukh and Sarma, Nilendu and Biswas, Rupanwita and Roy, Jyoeeta and Mukherjee, Anita and Giri, Ashok K (2008) DNA Repair Deficiency Leads to Susceptibility to Develop Arsenic-Induced Premalignant Skin Lesions. Int. J. Cancer, 123 (2). pp. 283-287.
 
Relation http://dx.doi.org/10.1002/ijc.23478
http://www.eprints.iicb.res.in/289/