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Evidence for Heterogeneous Nuclear Ribonucleoprotein K Overexpression in Oral Squamous Cell Carcinoma

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Field Value
 
Title Evidence for Heterogeneous Nuclear Ribonucleoprotein K
Overexpression in Oral Squamous Cell Carcinoma
 
Creator Roychoudhury, P
Chaudhuri, Keya
 
Subject Molecular & Human Genetics
 
Description The recent paper of Carpenter et al (2006b) in your journal
identified hnRNP K as being overexpressed in colorectal cancer by proteomics, which has been confirmed by immunohistochemistry and tissue microarray analysis. Their study also showed that hnRNP K had an aberrant subcellular localisation in cancer cells. Although there were previous reports by Moumen et al (2005), suggesting that, in response to DNA damage, p53 inhibits hnRNP K ubiquitin-dependent proteasomal degradation, the study by
Carpenter et al (2006a) could not, however, find any correlation between the expression of hnRNP K and p53 in colorectal cancer cells. We note the above observations with interest, as hnRNP K has a role in tumorigenesis and its expression has been found to be upregulated in several other cancers, including those of lungs and
liver (Carpenter et al, 2006a).
 
Date 2007
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/304/1/BRITISH_JOURNAL_OF_CANCER%2C_97(4)%2C574%2D575[50].pdf
Roychoudhury, P and Chaudhuri, Keya (2007) Evidence for Heterogeneous Nuclear Ribonucleoprotein K Overexpression in Oral Squamous Cell Carcinoma. British Journal of Cancer, 97. pp. 574-575.
 
Relation http://dx.doi.org/10.1038/sj.bjc.6603911
http://www.eprints.iicb.res.in/304/