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Reactivity of polyaminocarboxylatoruthenium(III) complexes with serine and their protease inhibition

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Title Reactivity of polyaminocarboxylatoruthenium(III)
complexes with serine and their protease inhibition
 
Creator Chatterjee, Debabrata
Sengupta, Ayon
Mitra , Anannya
Basak, Susan
Bhattacharyya, Reema
Bhattacharyya, Debasish
 
Subject Structural Biology & Bioinformatics
 
Description Reaction of [Ru(edta)(H2O)]� (edta4�¼ethylenediaminetetraacetate), [Ru(pdta)(H2O)]�
(pdta4�¼propylenediaminetetraacetate) and [Ru(hedtra)(H2O)] (hedtra3�¼N-hydroxyethylethylenediaminetriacetate)
with S-serine (Ser) was studied spectrophotometrically and
kinetically. Serine protease inhibition studies were performed with the three complexes
using the serine protease enzymes chymotrypsin and subtilisin with azoalbumin as
substrate. Results are discussed in terms of the reactivity of the Ru-pac (pac¼polyaminopolycarboxylates)
complexes with serine. The order of protease inhibition efficacy of the Ru-pac
complexes is [Ru(pdta)(H2O)]�>[Ru(edta)(H2O)]��[Ru(hedtra)(H2O)], in good agreement
with the observed reactivity of Ru-pac complexes with serine.
 
Publisher Taylor & Francis
 
Date 2005
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/325/1/JOURNAL_OF_COORDINATION_CHEMISTRY_58(18)1703%2D1711;2005[2].pdf
Chatterjee, Debabrata and Sengupta, Ayon and Mitra , Anannya and Basak, Susan and Bhattacharyya, Reema and Bhattacharyya, Debasish (2005) Reactivity of polyaminocarboxylatoruthenium(III) complexes with serine and their protease inhibition. Journal of Coordination Chemistry, 58 (18). pp. 1703-1711. ISSN 0095-8972
 
Relation http://dx.doi.org/10.1080/00958970500247487
http://www.eprints.iicb.res.in/325/